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Analysis of Tuberculosis Data in the Niono Health District in Mali from 2016 to 2024

Received: 5 March 2026     Accepted: 17 March 2026     Published: 27 March 2026
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Abstract

Introduction: Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis (Koch's bacillus) and remains a major public health problem in many developing countries. This study aimed to analyze tuberculosis data from the Niono health district in Mali from 2016 to 2024. Methodology: This was a cross-sectional study conducted using routine data collected from Referral Health Centers (CSRef) and selected Community Health Centers (CSCom) in the Niono district. The study covered data from 2016 to 2024. We analyzed annual incidence rates, the proportions of new cases and relapses, and mortality rates. Data confidentiality was maintained through coding throughout the study. Results: A total of 6,711 suspected TB cases, of which 718 were confirmed (a positivity rate of 10.7%), were recorded in the Niono health district database from 2016 to 2024. Tuberculosis incidence increased from 22.1 cases per 100,000 people in the Niono district in 2021 to 26.7 in 2024. The district saw a high proportion of incident cases in 2024 (19.3%). Notification to community health centers was the most common method, at 35.6%. The district experienced frequent relapses in 2019 and 2024 (18.8% and 18%, respectively). 99% of tuberculosis cases were treated at referral health centers. The mortality rate was estimated at 1.3%. Conclusion: Tuberculosis persists in the Niono health district, with the number of cases fluctuating and rising. The implementation of national strategies is necessary to achieve the objectives of a significant reduction.

Published in Science Journal of Public Health (Volume 14, Issue 2)
DOI 10.11648/j.sjph.20261402.12
Page(s) 68-73
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2026. Published by Science Publishing Group

Keywords

Tuberculosis, Incidence, Niono District

1. Introduction
Tuberculosis (TB) is an infectious, contagious disease, primarily transmitted from person to person, caused mainly by Mycobacterium tuberculosis or Koch 's bacillus . For several decades, TB was the leading cause of death from a single infectious agent. The remains a major scourge with more than 8 million new cases and 3 million deaths annually worldwide
The World Health Organization (WHO) has recorded 10.8 million new tuberculosis infections worldwide, including 6 million men, 3.6 million women, and 1.3 million children, with an estimated mortality of 1.25 million deaths directly attributable to the disease in 2023 .
Africa has seen a decline in tuberculosis deaths and cases, from 2.5 million cases and 424,000 tuberculosis deaths in 2022 to 1.9 million cases in 2023 . It bears a significant share of the global tuberculosis burden, with 1.6 million new cases and over 600,000 deaths each year . For example, in Côte d'Ivoire, 20,000 cases of tuberculosis (125 cases per 100,000 inhabitants) are recorded annually .
In developing countries, the situation is exacerbated by structural factors such as limited access to care, inadequate health infrastructure, and socioeconomic inequalities . These obstacles compromise the effectiveness of control policies, despite the improvement in the detection rate in the African Region, which increased from 60% to 70% between 2020 and 2022 .
In Mali, data show that tuberculosis persists despite progress in control and research, remaining a major public health problem . WHO estimates indicate that in 2018, the incidence rate was 53 cases per 100,000 inhabitants . A downward trend is observed, with 48 cases per 100,000 inhabitants in 2023 and 37 cases per 100,000 inhabitants in 2024 .
The Ségou region has a tuberculosis incidence of 55 cases per 100,000 inhabitants . The Niono health district in the region recorded 4,168 suspected and 811 confirmed cases of tuberculosis from 2016 to 2024 . These data have not been analyzed to assess the implementation of TB control strategies. The main objective of our work was to analyze these data. More specifically, it allowed us to:
1) Calculate the frequency of tuberculosis in the Niono health district.
2) Determine the number of new cases and relapses in the Niono health district,
3) Determine the number of systematic tuberculosis screenings in people living with human immunodeficiency virus (HIV),
4) Determine the tuberculosis death rate in the Niono health district.
This study will provide a better understanding of the evolution of TB in the Niono health district from 2016 to 2024, thereby strengthening targeted interventions by health authorities.
2. Materials and Methods
2.1. Study Framework
The current study took place in the Niono health district, located in the Ségou region, the fourth administrative region of Mali. The district covers an area of 23,063 km2 with a population of approximately 575,123 inhabitants in 2024 and a density of 22 inhabitants/km2 . It is structured into two levels of care: the first, represented by twenty-six (26) community health centers (CSCom), and the second, the referral health center (CSRef).
2.2. Type and Period of Study
This was a cross-sectional study conducted from February to July 2025. It focused on tuberculosis data from the Niono health district in Mali from 2016 to 2024.
2.3. Study Population
(DHIS 2) database from 2016 to 2024.
Suspected case: Pulmonary tuberculosis is often suspected based on one of the following criteria: A chest X-ray taken to look for respiratory symptoms (cough lasting > 3 weeks, hemoptysis, chest pain, dyspnea), unexplained illness, fever of unknown origin, or a positive tuberculin skin test
A confirmed case of tuberculosis is a patient in whom the presence of the responsible bacterium, Mycobacterium tuberculosis, has been proven by laboratory tests
A case of relapse is defined as a patient who has already taken antituberculosis drugs for one month or more and whose final result of the last antituberculosis treatment was "cured" or "treatment completed" and who presents with a recurrent episode of TB (true relapse or reinfection) .
2.4. Data Collection
We extracted the data from the Mali District Health Information Software (DHIS2) database.
Data processing was performed using Microsoft Excel 2016.
We analyzed the tuberculosis database by time, place, and person.
3. Results
A total of 6711 suspected TB cases, of which 718 were confirmed, representing a positivity rate of 10.7%, were recorded in the Niono health district database from 2016 to 2024 (Tables 1 and 2).
Table 1. Distribution of suspected TB cases in the Niono health district from 2016 to 2024.

Year

Health facilities

Total

CSCom

CSRef

n

%

n

%

n

%

2016

191

26.7

159

5.2

350

5.2

2017

45

6.3

352

11.6

397

5.9

2018

79

11.0

461

15.2

540

8.0

2019

36

5.0

378

12.4

414

6.2

2020

26

3.6

159

5.2

185

2.8

2021

29

4.1

193

6.3

222

3.1

2022

45

6.3

301

9.9

346

5.2

2023

103

14.4

399

13.1

502

7.5

2024

161

22.5

638

21.0

3755

55.6

Total

715

100.0

3040

100.0

6711

100.0

n= number of suspected tuberculosis cases
Table 2. Distribution of confirmed TB cases in the Niono health district from 2016 to 2024.

Year

Health facility

Total

CSCom (n)

CSRef (n)

n

%

n

%

n

%

2016

6

10.2

40

5.6

46

5.9

2017

8

13.6

69

9.6

77

9.9

2018

7

11.9

71

9.9

78

10.0

2019

3

5.1

58

8.1

61

7.8

2020

7

11.9

33

4.6

40

5.1

2021

4

6.8

113

15.7

117

15.0

2022

3

5.1

84

11.7

87

11.2

2023

0

0.0

122

17.0

122

15.7

2024

21

35.6

129

17.9

150

19.3

Total

59

100.0

719

100.0

778

1000

n = number of confirmed cases of tuberculosis.
The district experienced a high proportion of incident cases in 2024 at 19.3%. Notification in community health centers was the most represented at 35.6%.
Figure 1. TB trend in the Niono health district from 2016 to 2024.
Since 2020 we have seen an increase in the trend of TB cases.
Table 3. TB relapse cases in the Niono health district from 2016 to 2024.

Year

Health facility

Total

CSCom (n)

CSRef (n)

n

%

n

%

n

%

2016

0

0.0

0

0.0

0

0.0

2017

0

0.0

0

0.0

0

0.0

2018

0

0.0

0

0.0

0

0.0

2019

0

0.0

138

18.9

138

18.8

2020

0

0.0

121

16.6

121

16.5

2021

0

0.0

116

15.9

116

15.8

2022

0

0.0

108

14.8

108

14.7

2023

0

0.0

119

16.3

119

16.2

2024

5

100.0

127

17.4

132

18.0

Total

5

100.0

729

100.0

734

100.0

The district experienced frequent cases of relapse in 2019 and 2024 with 18.8% and 18% respectively.
4. Discussion
4.1. Boundaries
Our study was limited by the quality of the data in the care facilities, due to its incompleteness (several items were not completed). We also noted inconsistencies that limited comparisons between care facilities of the same level.
4.2. Frequency of TB in the Niono Health District
The incidence of tuberculosis cases in the Niono health district is trending upward, peaking at 26.7 cases per 100,000 inhabitants in 2024. Although this rate is lower than the national average of 50 cases per 100,000 inhabitants according to the Global Tuberculosis Report 2023, this district warrants particular attention. This trend was observed only in 2021, according to our results (Table 2). This could be explained by the proper implementation of strategies recommended by the Ministry of Health, through intensified screening activities by community teams . Our results are consistent with those of the study by Sanogo et al in the Mopti region in 2020 . A survey conducted in Kayes by Boubacar Niaré et al in 2023, with screening in 12 mosques in Bamako, indicates a detection rate of 1.64% (≈1,640 per 100,000), thus confirming a potentially underestimated incidence in rural areas .
4.3. Relapse and New Cases of TB in the Niono District
The Niono district recorded a considerable proportion of tuberculosis cases, at 19% and 18% respectively, including both first diagnoses and relapses in 2019 and 2024. Recent tuberculosis exposure was found in 37% of cases in the study by S. Majdoub Fehri et al. in Tunisia . The lack of distinction between new cases and relapses in the Niono district database could explain this difference in proportion. Relapses are associated with an increased risk of developing drug-resistant forms of tuberculosis. Ansa et al in Ghana in 2012 observed that the integration of TB/HIV services significantly reduced relapse rates by improving follow-up and support for vulnerable patients .
4.4. TB Trends in the Niono Health District
From 2016 to 2024, we witnessed a fluctuation in TB cases, expressed between 2016 to 2019 and 2020 to 2024.
The specific lethality was estimated at 1.3% (10/778) from 2016 to 2024, exclusively within the Reference Health Centers (CSRéf). This rate remains lower than the national average reported in the 2023 national annual report, which estimates the tuberculosis case fatality rate at around 6% . This difference is explained by the fact that our study considers confirmed cases, whereas the national average includes notified cases, which may encompass all suspected and confirmed cases. This situation illustrates that, despite a relatively lower mortality rate in Niono, each death reveals classic risk factors: late diagnosis, poorly managed HIV co-infection, and treatment interruptions, consistent with the findings of the national program. In the same region as Niono, Coulibaly et al. observed a case fatality rate of 8.3% in Konobougou, in the Baroueli district, in 2020, significantly higher than that of our study . Similarly, the study conducted by Ousmane Sy et al. in the Djenné health district in 2024 reported a case fatality rate of 11.7% . In the two previous studies, the differences could also be explained by the methods (study designs, data collection methods) and the study populations.
5. Conclusion and Recommendations
Tuberculosis remains prevalent in the Niono district. The number of relapses remains significant in our context, highlighting the need for regular patient follow-up. We recommend rigorous data collection in the district health database to support the implementation of national strategies, such as prompt case reporting and treatment initiation.
6. Ethical Considerations
Access to sensitive information contained in the database was subject to prior authorization in accordance with applicable regulations for scientific research. Furthermore, the confidentiality of the information collected was a top priority. The data collected were used exclusively within the scientific framework of this tuberculosis research, with enhanced safeguards against unauthorized disclosure. Data processing complied with applicable international and national standards in medical and scientific research, while contributing to improved knowledge of tuberculosis and public health strategies.
Abbreviations

CSCom

Community Health Centers

CSRef

Referral Health Centers

DERSP

Department of Teaching and Research in Public Health and Specialties

DHIS2

District Health Information Software

HIV

Human Immunodeficiency Virus

INSP

National Institute of Public Health

TB

Tuberculosis

UCRC

4University Clinical Research Center

USTTB

University of Sciences, Techniques and Technologies of Bamako

WHO

World Health Organization

Author Contributions
Oumar Sangho: Conceptualization, Formal Analysis, Methodology, Supervision, Validation, Visualization, Writing – original draft
Fanta Sangho: Methodology, Supervision, Validation, Writing – review & editing
Djibril Barry: Formal Analysis, Methodology, Validation, Writing – original draft, Writing – review & editing
Aminata Diangana: Conceptualization, Data curation, Formal Analysis, Investigation, Methodology, Visualization, Writing – review & editing
Lancina Doumbia: Validation, Writing – review & editing
Abou Sogodogo: Formal Analysis, Methodology, Validation, Writing – review & editing
Amadou Youssouf Toure: Validation, Writing – review & editing
Mamatal Ag Intagriste: Validation, Writing – review & editing
Mariam Traore: Validation, Writing – review & editing
Mouhamadou Traore: Validation, Writing – review & editing
Ousmane Doumbia: Validation, Writing – review & editing
Yaya Togo: Validation, Writing – review & editing
Abdoul Salam Diarra: Validation, Writing – review & editing
Borodjan Diarra: Validation, Writing – review & editing
Ousmane Boua Togola: Validation, Writing – review & editing
Cheick Abou Coulibaly: Validation, Writing – review & editing
Conflicts of Interest
The authors declare that they have no conflict of interest in this work.
References
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[12] Sectoral Unit for the Fight against HIV/AIDS, Tuberculosis and Viral Hepatitis, Mali. Annual Report 2024.
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[15] World Health Organization. 1.3 Drug-resistant TB [Internet]. [cited 1 Dec 2025]. Available from:
[16] Sanogo M, Kone B, Diarra B, Maiga M, Baya B, Somboro AM, Sarro YS, Togo ACG, Dembele BPP, Goita D, Kone A, M'Baye O, Coulibaly N, Diabate S, Traore B, Diallo MH, Coulibaly YI, Saleeb P, Belson M, Orsega S, Siddiqui S, Polis MA, Dao S, Murphy RL, Diallo S. Performance of microscopic observation drug susceptibility for the rapid diagnosis of tuberculosis and detection of drug resistance in Bamako, Mali. Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis. June 2017; 23(6): 408. e1-408. e6.
[17] Niaré B, Traoré Y, Keita C, Diallo O, Diarra S, Ba K, Touré S, Keita M, Coulibaly O, Traoré A, Diarra B, Traoré M, Coulibaly MB, Konake MS, Coulibaly AB. Active Screening for Tuberculosis in Sub-Saharan Africa: The Case of Mosques in the District of Bamako (Mali). SAS J Med [Internet]. 23 June 2023 [cited 1 Dec 2025]; 9(06): 704-8. Available from:
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[19] Mjid M, Hedhli A, Zakhma M, Zribi M, Ouahchi Y, Toujani S, Cherif J. Clinical and microbiological profile of patients with relapsed tuberculosis in Tunisia. Rev Pneumol Clin [Internet]. 1 Apr 2018 [cited 1 Dec 2025]; 74(2): 76-80. Available from:
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[23] Ousmane SY, Karamoko Djiguiba, Cheickne Hamala Kome, Sidy Sangare, Fanta Niare, Lamine Doumbia. Epidemiological aspects of pulmonary tuberculosis in the Djenné health district, Mali. Journal of Epidemiology and Public Health, 2(4), 1-5 [Internet]. 2024 [cited 1 Dec 2025].
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    Sangho, O., Sangho, F., Barry, D., Diangana, A., Doumbia, L., et al. (2026). Analysis of Tuberculosis Data in the Niono Health District in Mali from 2016 to 2024. Science Journal of Public Health, 14(2), 68-73. https://doi.org/10.11648/j.sjph.20261402.12

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    Sangho, O.; Sangho, F.; Barry, D.; Diangana, A.; Doumbia, L., et al. Analysis of Tuberculosis Data in the Niono Health District in Mali from 2016 to 2024. Sci. J. Public Health 2026, 14(2), 68-73. doi: 10.11648/j.sjph.20261402.12

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    AMA Style

    Sangho O, Sangho F, Barry D, Diangana A, Doumbia L, et al. Analysis of Tuberculosis Data in the Niono Health District in Mali from 2016 to 2024. Sci J Public Health. 2026;14(2):68-73. doi: 10.11648/j.sjph.20261402.12

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  • @article{10.11648/j.sjph.20261402.12,
      author = {Oumar Sangho and Fanta Sangho and Djibril Barry and Aminata Diangana and Lancina Doumbia and Abou Sogodogo and Amadou Youssouf Toure and Mamatal Ag Intagriste and Mariam Traore and Mouhamadou Traore and Ousmane Doumbia and Yaya Togo and Abdoul Salam Diarra and Borodjan Diarra and Ousmane Boua Togola and Cheick Abou Coulibaly},
      title = {Analysis of Tuberculosis Data in the Niono Health District in Mali from 2016 to 2024},
      journal = {Science Journal of Public Health},
      volume = {14},
      number = {2},
      pages = {68-73},
      doi = {10.11648/j.sjph.20261402.12},
      url = {https://doi.org/10.11648/j.sjph.20261402.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20261402.12},
      abstract = {Introduction: Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis (Koch's bacillus) and remains a major public health problem in many developing countries. This study aimed to analyze tuberculosis data from the Niono health district in Mali from 2016 to 2024. Methodology: This was a cross-sectional study conducted using routine data collected from Referral Health Centers (CSRef) and selected Community Health Centers (CSCom) in the Niono district. The study covered data from 2016 to 2024. We analyzed annual incidence rates, the proportions of new cases and relapses, and mortality rates. Data confidentiality was maintained through coding throughout the study. Results: A total of 6,711 suspected TB cases, of which 718 were confirmed (a positivity rate of 10.7%), were recorded in the Niono health district database from 2016 to 2024. Tuberculosis incidence increased from 22.1 cases per 100,000 people in the Niono district in 2021 to 26.7 in 2024. The district saw a high proportion of incident cases in 2024 (19.3%). Notification to community health centers was the most common method, at 35.6%. The district experienced frequent relapses in 2019 and 2024 (18.8% and 18%, respectively). 99% of tuberculosis cases were treated at referral health centers. The mortality rate was estimated at 1.3%. Conclusion: Tuberculosis persists in the Niono health district, with the number of cases fluctuating and rising. The implementation of national strategies is necessary to achieve the objectives of a significant reduction.},
     year = {2026}
    }
    

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  • TY  - JOUR
    T1  - Analysis of Tuberculosis Data in the Niono Health District in Mali from 2016 to 2024
    AU  - Oumar Sangho
    AU  - Fanta Sangho
    AU  - Djibril Barry
    AU  - Aminata Diangana
    AU  - Lancina Doumbia
    AU  - Abou Sogodogo
    AU  - Amadou Youssouf Toure
    AU  - Mamatal Ag Intagriste
    AU  - Mariam Traore
    AU  - Mouhamadou Traore
    AU  - Ousmane Doumbia
    AU  - Yaya Togo
    AU  - Abdoul Salam Diarra
    AU  - Borodjan Diarra
    AU  - Ousmane Boua Togola
    AU  - Cheick Abou Coulibaly
    Y1  - 2026/03/27
    PY  - 2026
    N1  - https://doi.org/10.11648/j.sjph.20261402.12
    DO  - 10.11648/j.sjph.20261402.12
    T2  - Science Journal of Public Health
    JF  - Science Journal of Public Health
    JO  - Science Journal of Public Health
    SP  - 68
    EP  - 73
    PB  - Science Publishing Group
    SN  - 2328-7950
    UR  - https://doi.org/10.11648/j.sjph.20261402.12
    AB  - Introduction: Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis (Koch's bacillus) and remains a major public health problem in many developing countries. This study aimed to analyze tuberculosis data from the Niono health district in Mali from 2016 to 2024. Methodology: This was a cross-sectional study conducted using routine data collected from Referral Health Centers (CSRef) and selected Community Health Centers (CSCom) in the Niono district. The study covered data from 2016 to 2024. We analyzed annual incidence rates, the proportions of new cases and relapses, and mortality rates. Data confidentiality was maintained through coding throughout the study. Results: A total of 6,711 suspected TB cases, of which 718 were confirmed (a positivity rate of 10.7%), were recorded in the Niono health district database from 2016 to 2024. Tuberculosis incidence increased from 22.1 cases per 100,000 people in the Niono district in 2021 to 26.7 in 2024. The district saw a high proportion of incident cases in 2024 (19.3%). Notification to community health centers was the most common method, at 35.6%. The district experienced frequent relapses in 2019 and 2024 (18.8% and 18%, respectively). 99% of tuberculosis cases were treated at referral health centers. The mortality rate was estimated at 1.3%. Conclusion: Tuberculosis persists in the Niono health district, with the number of cases fluctuating and rising. The implementation of national strategies is necessary to achieve the objectives of a significant reduction.
    VL  - 14
    IS  - 2
    ER  - 

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